| Novel preclinical gastroenteropancreatic neuroendocrine neoplasia models demonstrate the feasibility of mutation-based targeted therapy.
Viol F, Sipos B, Fahl M, Clauditz TS, Amin T, Kriegs M, Nieser M,
Izbicki JR, Huber S, Lohse AW, Schrader J.
Cell Oncol (Dordr). 2022 Dec;45(6):1401-1419.
Analysis on the healing of gastrointestinal ulceration by using Hemospray
Werner CR, Brücklmeier L, Kratt T, Malek NP, Sipos B,
Wichmann D, Götz M.
Sci Rep. 2021 Sep 24;11(1):19050.
FGF-Receptors and PD-L1 in Anaplastic and Poorly Differentiated Thyroid Cancer: Evaluation of the Preclinical Rationale.
Adam P, Kircher S, Sbiera I, Koehler VF, Berg E, Knösel T, Sandner B, Fenske WK, Bläker H, Smaxwil C, Zielke A, Sipos B, Allelein S, Schott M,
Dierks C, Spitzweg C, Fassnacht M, Kroiss M.
Front Endocrinol (Lausanne). 2021 Aug 12;12:712107.
Combined effects of PNPLA3, TM6SF2 and HSD17B13 variants on severity of biopsy-proven non-alcoholic fatty liver disease.
Paternostro R, Staufer K, Traussnigg S, Stättermayer AF, Halilbasic E, Keritam O, Meyer EL, Stift J, Wrba F, Sipos B, Canbay A, Schlattjan M,
Aigner E, Datz C, Stickel F, Schafmayer C, Hampe J, Buch S, Prager G,
Munda P, Mandorfer M, Ferenci P, Trauner M.
Hepatol Int. 2021 Aug;15(4):922-933. doi: 10.1007/s12072-021-10200-y. Epub 2021 Jun 2.
CUX1 Enhances Pancreatic Cancer Formation by Synergizing with KRAS and Inducing MEK/ERK-Dependent Proliferation
Griesmann H, Mühl S, Riedel J, Theuerkorn K, Sipos B, Esposito I, Vanden, Heuvel GB, Michl P.
Cancers (Basel). 2021, May 18;13(10):2462.
Platelet-Expressed Synaptophysin (pSyn) as Novel Biomarker in Neuroendocrine Malignancies. Cancers (Basel).
Hinterleitner M, Sipos B, Wagner V, Grottenthaler JM, Lauer UM,
Zender L, Hinterleitner C.
2021 May 11;13(10):2286.
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.
Wiedenmann S, Cohrs CM, Perkhofer L, Jain G, Krüger J, Hermann PC, Schmid M,Madácsy T, Varga Á, Griger J, Azoitei N, Müller M, Wessely O, Robey PG, Heller,S, Dantes Z, Reichert M, Günes C, Bolenz C, Kuhn F, Maléth J, Speier S, Liebau, S, Sipos B, Kuster B, Seufferlein T, Rad R, Meier M, Hohwieler M, Kleger A.
Cell Stem Cell. 2021 Jun 3;28(6):1105-1124.e19.
Exploiting the MUC5AC Antigen for Noninvasive Identification of Pancreatic Cancer.
Henry KE, Shaffer TM, Mack KN, Ring J, Ogirala A, Klein-Scory S,
Eilert-Micus C, Schmiegel W, Bracht T, Sitek B, Clyne M, Reid CJ, Sipos B,
Lewis JS, Kalthoff H, Grimm J.
J Nucl Med. 2021 Oct;62(10):1384-1390.
Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer.
Werle SD, Schwab JD, Tatura M, Kirchhoff S, Szekely R, Diels R,
Ikonomi N, Sipos B, Sperveslage J, Gress TM, Buchholz M, Kestler HA.
Cancers (Basel). 2021 Feb 10;13(4):725
An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer.
Zekri L, Vogt F, Osburg L, Müller S, Kauer J, Manz T, Pflügler M, Maurer A, Heitmann JS, Hagelstein I, Märklin M, Hörner S, Todenhöfer T,
Calaminus C, Stenzl A, Pichler B, la Fougère C, Schneider MA, Rammensee HG, Zender L,
Sipos B, Salih HR, Jung G.
EMBO Mol Med. 2021 Feb 5;13(2):e11902.
Immunoprofiling in Neuroendocrine Neoplasms Unveil Immunosuppressive Microenvironment.
Busse A, Mochmann LH, Spenke C, Arsenic R, Briest F, Jöhrens K,
Lammert H, Sipos B, Kühl AA, Wirtz R, Pavel M, Hummel M,
Kaemmerer D, Baum RP, Grabowski P.
Cancers (Basel). 2020 Nov 19;12(11):3448.
Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation.
Smith DK, Kates L, Durinck S, Patel N, Stawiski EW, Kljavin N, Foreman O, Sipos B, Solloway MJ, Allan BB, Peterson AS.
Cell Rep Med. 2020 Aug 25;1(5):100058.
Targeting interleukin 6 signaling by monoclonal antibody siltuximab on cholangiocarcinoma.
J Nguyen MLT, Bui KC, Scholta T, Xing J, Bhuria V, Sipos B, Wilkens L,
Nguyen Linh T, Velavan TP, Bozko P, Plentz RR.
Gastroenterol Hepatol. 2021 May;36(5):1334-1345.
Necroptosis microenvironment directs lineage commitment in liver cancer.
Seehawer M, Heinzmann F, D’Artista L, Harbig J, Roux PF, Hoenicke L, Dang H, Klotz S, Robinson L, Doré G, Rozenblum N, Kang TW, Chawla R, Buch T, Vucur M, Roth M, Zuber J, Luedde T, Sipos B, Longerich T, Heikenwälder M, Wang XW, Bischof O, Zender L.
Nature. 2018 Oct;562(7725):69-75.
S2k-Leitlinie Neuroendokrine Tumore AWMF-Reg. 021-27
Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS); Netzwerk Neuroendokrine Tumoren (NeT) e.V. (Patientenvertretung); Bundesorganisation Selbsthilfe NeuroEndokrine Tumoren e.V. (NET-sgh) (Patientenvertretung); Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V. (DGHO), und Arbeitsgemeinschaft Internistische Onkologie (AIO) der Deutschen Krebsgesellschaft e.V; Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie e.V. (DGAV); Deutsche Gesellschaft für Chirurgie (DGCH); Deutsche Gesellschaft für Endoskopie und Bildgebende Verfahren (DGEBV); Deutsche Gesellschaft für Nuklearmedizin e.V. (DGNM); Deutsche Gesellschaft für Innere Medizin (DGIM); Deutsche Gesellschaft für Endokrinologie (DGE); Deutsche Gesellschaft für Palliativmedizin e.V. (DGP); Deutsche Röntgengesellschaft e.V. (DRG); Deutsche Gesellschaft für Pathologie e.V./Bundesverband Deutscher Pathologen (DGP/BDP); Deutsche Gesellschaft für interventionelle Radiologie (DGiR); Authors; Collaborators:.
Z Gastroenterol. 2018 Jun;56(6):583-681. Epub 2018 Jun 11. German.
Therapeutic Targeting of Tumor-Associated Macrophages in Pancreatic Neuroendocrine Tumors.
Krug S, Abbassi R, Griesmann H, Sipos B, Wiese D, Rexin P, Blank A, Perren A, Haybaeck J, Hüttelmaier S, Rinke A, Gress TM, Michl P.
Int J Cancer. 2018 Apr 26. [Epub ahead of print]
Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal adenocarcinomas than to neuroendocrine tumors G3.
Konukiewitz B, Jesinghaus M, Steiger K, Schlitter AM, Kasajima A,
Sipos B, Zamboni G, Weichert W, Pfarr N, Klöppel G.
Hum Pathol. 2018 Jul;77:70-79.. Epub 2018 Mar 26.
[Neuroendocrine neoplasms of the auditory, olfactory, and visual sensory organs].
Sipos B.
Pathologe. 2018 May;39(3):255-263.. Review. German.
MAFA missense mutation causes familial insulinomatosis and diabetes mellitus.
Iacovazzo D, Flanagan SE, Walker E, Quezado R, de Sousa Barros FA, Caswell R, Johnson MB, Wakeling M, Brändle M, Guo M, Dang MN, Gabrovska P, Niederle B, Christ E, Jenni S, Sipos B, Nieser M, Frilling A, Dhatariya K, Chanson P, de Herder WW, Konukiewitz B, Klöppel G, Stein R, Korbonits M, Ellard S.
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1027-1032.
Somatostatin receptor expression related to TP53 and RB1 alterations in pancreatic and extrapancreatic neuroendocrine neoplasms with a Ki67-index above 20.
Konukiewitz B, Schlitter AM, Jesinghaus M, Pfister D, Steiger K, Segler A, Agaimy A, Sipos B, Zamboni G, Weichert W, Esposito I, Pfarr N, Klöppel G.
Mod Pathol. 2017 Apr;30(4):587-598.
ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage.
Perkhofer L, Schmitt A, Romero Carrasco MC, Ihle M, Hampp S, Ruess DA, Hessmann E, Russell R, Lechel A, Azoitei N, Lin Q, Liebau S, Hohwieler M, Bohnenberger H, Lesina M, Algül H, Gieldon L, Schröck E, Gaedcke J, Wagner M, Wiesmüller L, Sipos B, Seufferlein T, Reinhardt HC, Frappart PO, Kleger A.
Cancer Res. 2017 Oct 15;77(20):5576-5590.
Defects in myosin VB are associated with a spectrum of previously undiagnosed low γ-glutamyltransferase cholestasis.
Qiu YL, Gong JY, Feng JY, Wang RX, Han J, Liu T, Lu Y, Li LT, Zhang MH, Sheps JA, Wang NL, Yan YY, Li JQ, Chen L, Borchers CH, Sipos B, Knisely AS, Ling V, Xing QH, Wang JS.
Hepatology. 2017 May;65(5):1655-1669.
Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice.
Jandaghi P, Najafabadi HS, Bauer AS, Papadakis AI, Fassan M, Hall A, Monast A, von Knebel Doeberitz M, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Sipos B, Auld D, Lathrop M, Park M, Büchler MW, Strobel O, Hackert T, Giese NA, Zogopoulos G, Sangwan V, Huang S, Riazalhosseini Y, Hoheisel JD.
Gastroenterology. 2016 Dec;151(6):1218-1231.
RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.
Lesina M, Wörmann SM, Morton J, Diakopoulos KN, Korneeva O, Wimmer M, Einwächter H, Sperveslage J, Demir IE, Kehl T, Saur D, Sipos B, Heikenwälder M, Steiner JM, Wang TC, Sansom OJ, Schmid RM, Algül H.
J Clin Invest. 2016 Aug 1;126(8):2919-32.
Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma Remains.
Nieser M, Henopp T, Brix J, Stoß L, Sitek B, Naboulsi W, Anlauf M, Schlitter AM, Klöppel G, Gress T, Moll R, Bartsch DK, Heverhagen AE, Knoefel WT, Kaemmerer D, Haybaeck J, Fend F, Sperveslage J, Sipos B.
Neuroendocrinology. 2017;104(3):302-312.
The role of integrins in primary and secondary brain tumors.
Schittenhelm J, Tabatabai G, Sipos B.
Histol Histopathol. 2016 Oct;31(10):1069-78. Review.
Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer.
Griesmann H, Drexel C, Milosevic N, Sipos B, Rosendahl J, Gress TM, Michl P.
Gut. 2017 Jul;66(7):1278-1285.
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT. Nat Med. 2015 Oct;21(10):1163-71.
Glucagon cell hyperplasia and neoplasia with and without glucagon receptor mutations.
Sipos B, Sperveslage J, Anlauf M, Hoffmeister M, Henopp T, Buch S, Hampe J, Weber A, Hammel P, Couvelard A, Höbling W, Lieb W, Boehm BO, Klöppel G.
J Clin Endocrinol Metab. 2015 May;100(5):E783-8. |
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